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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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References:
  1. : Manforce.com - erectile dysfunction medication
Reference

Sildenafil (generic Viagra) is a prescription-only medication that contains the active ingredient sildenafil citrate. It is available for use echosensitive to sexual stimulation...

IMPORTANT NOTICE: Please be aware, prior to sale, you are advised to have a short phone call consultation with our Pharmacist. Automatic purchase consents the Pharmacist to give you a quick call.

Viagra Connect is available without a Prescription but requires a brief consultation with the Pharmacist. It is available in a 4 pack or an 8 pack. Viagra Connect contains Sildenafil 50mg which works by relaxing the penis blood vessels, allowing blood to flow when you get aroused causing erections and potency. Viagra Connect will only help men become erect if you are aroused. Only for adult use, men 18 years plus.

How to be taken:

  • The recommended dose is one 50 mg tablet taken with water approximately one hour before bedtime activity
  • The maximum recommended dosing frequency is once per day
  • The onset of sexual activity may be delayed if Viagra Connect is taken with food, compared to without food
  • Please read Instructions provided with the product carefully before taking.

VIAGRA CONNECT is not to be taken if:

  • There is no problem with gaining erections.
  • Nitrate medicine is taken for chest pain or heart failure
  • Amyl nitrite, so-called “poppers”, is taken as recreational drugs
  • Riociguat (or other guanylate cyclase stimulators) is taken for high blood pressure in the lungs
  • Ritonavir is taken for the treatment of HIV
  • Your Doctor has advised you to avoid activity because of a problem with your heart or blood vessels
  • You have a heart problem such as a recent heart attack or stroke (within the last 6 months), Chest pain (Angina) or severe Heart failure (reduced pumping capacity of the heart)
  • You have a liver problem
  • You have low blood pressure (below 90/50 mmHg) which can cause symptoms such as tiredness, dizziness, light-headedness, feeling sick, clammy skin, depression, loss of consciousness, or blurry vision
  • Loss of vision has occurred before because of nerve damage in the eyes, such as non-arteritic anterior ischaemic optic neuropathy (NAION); or have a rare inherited eye disease, such as retinitis pigmentosa
  • You have a deformed penis
  • You are a woman
  • You are under 18 years of age
  • You are allergic to sildenafil or any of the other ingredients of this medicine

Please read instructions carefully provided.

Viagra Connect is a fast acting drug for erectile dysfunction which can last up to 4 hours and takes effect within 30 minutes after administration.

Sildenafil Citrate 50 mg Tablets: This tablet is specifically formulated to treat the symptoms of erectile disfunction and is highly effective in treating it, the most common sexual disorder affecting men over the age of 40 years. Provides a solution to erectile dysfunction in men who suffer from impotence due to conditions such as heart disease or diabetes, or who have problems with their physical or mental health.

Viagra Connect ensures fast and effective results that last as long as 36 hours and come without side effects. It works by relaxing the blood vessels in the penis, allowing blood to flow into the phallus when you get sexually excited and causing the desired stiffness.

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Be sure to talk with your doctor before taking Viagra Connect since it may cause side effects such as headache, flushing, dizziness, nasal congestion, indigestion, visual disturbances (such as a change in vision), or prolonged painful erections. Some applications of this medicine may also be suitable for rare circumstances such as:

  • Erectile dysfunction with sexual discomfort (erectile dysfunction
  • Erectile dysfunction with a few mild mildest erectile dysfunction (impotence)
  • A sudden decrease or loss of vision in one or both eyes, such as a sudden decrease or loss of vision in the one or both eyes, so called “poiasis” (prevention)
  • Low blood pressure (below 90/50 mmHg)
  • Skin rash, itching, blisters, or ulcers (rare)
  • Chest pain
  • Yeast infection

There's no single answer to why Viagra is widely used to treat erectile dysfunction (ED). While it is typically prescribed for occasional ED, some research has suggested that Viagra can also be used to treat benign prostatic hyperplasia (BPH).

While many doctors consider BPH to be a benign condition, it can also be a sign of a more serious health condition called pulmonary arterial hypertension (PAH), or high blood pressure in the blood vessels of the lungs.

Pulmonary arterial hypertension occurs when the heart and blood vessels in the lungs narrow too fast, and if left untreated, it can lead to pulmonary edema (fluid retention) and stroke.

Viagra is also used to treat PAH. It relaxes the blood vessels in the lungs, allowing more blood to flow in and out of the lungs.

While Viagra is not FDA-approved for PAH, it's widely prescribed off-label for ED. Many doctors and patients consider it a safe and effective treatment for ED.

What Causes ED?

The cause of ED is often unknown but can range from physical symptoms (ED) to psychological factors like anxiety or depression.

ED is generally treatable, but it can also cause physical symptoms. Some common physical and psychological causes of ED include:

  • Stress: ED can lead to psychological symptoms.
  • Low self-esteem: ED can also contribute to a lack of confidence and self-esteem.
  • Obesity: Obesity can also increase blood pressure, which can cause ED.
  • Lack of exercise: ED can also contribute to a lack of energy and a lack of interest in activities that can benefit the person.
  • Depression: ED can also be caused by other mental health conditions, such as depression or mood disorders.

Psychological factors can also contribute to ED. For example, stress can increase anxiety or depression, which can cause ED.

ED is not a common cause of physical symptoms. However, it can have a significant impact on your overall health.

Psychological factors also can cause ED.

While there is no definitive proof that Viagra or other medications cause ED, there is anecdotal evidence suggesting that lifestyle factors can play a role.

How Do ED Medications Work?

Viagra and other ED medications help treat erectile dysfunction (ED).

Viagra belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. It works by relaxing the blood vessels in your penis, allowing more blood to flow into it when you get sexually excited.

PDE5 inhibitors work by blocking an enzyme called phosphodiesterase type 5 (PDE5). This allows more blood to flow into your penis when you get sexually excited, helping to achieve and maintain an erection.

It's important to note that while Viagra and other ED medications may help, they do not cure ED or cure the underlying cause.

In some cases, medical professionals may recommend trying other treatments to treat ED. For example, penile rehabilitation and vacuum devices may be effective treatments for ED.

However, as with any treatment, it's essential to consult a doctor before starting any new medication.

Does Viagra Cause ED?

There's not a lot of information about Viagra's effect on ED. However, many doctors and patients don't consider it a cause for ED.

There are several reasons Viagra may cause ED:

  • — ED can increase anxiety and stress. Anxiety can cause ED, which can contribute to ED.
  • — ED can also contribute to a lack of confidence and self-esteem.
  • — ED can be caused by other mental health conditions, such as depression or mood disorders.
  • — ED can also be caused by other medical conditions, such as diabetes or high blood pressure.
  • — ED can also be caused by poor concentration or poor physical activity.
  • — ED can also be caused by other medical conditions, such as depression or mood disorders.

A new study published in theNew England Journal of Medicinesuggests that a group of drugs in the blood-brain barrier could be used to prevent and treat Parkinson’s disease.

The researchers tested the effects of two popular drugs in the blood-brain barrier: sildenafil (sold as Viagra) and tadalafil (sold as Cialis). They looked at the effect of these drugs on brain function in animals.

The researchers found that a group of drugs (sildenafil, tadalafil) was associated with an increase in brain blood flow, a sign of an improvement in the level of brain-globosec and a reduction in motor control.

Sildenafil, the only FDA-approved drug for erectile dysfunction, is a PDE5 inhibitor that works by blocking PDE5, a group of chemicals found in the body’s blood that causes nitric oxide to be released. Nitric oxide then activates the enzyme guanylate cyclase. This results in the production of cyclic guanosine monophosphate (cGMP), which causes smooth muscle relaxation in the spinal cord.

Tadalafil, on the other hand, is a PDE5 inhibitor that works by blocking PDE5, a group of chemicals in the body that increases the levels of cGMP. This results in the production of cGMP, which causes smooth muscle relaxation and relaxation in the spinal cord. This action is thought to be the reason tadalafil causes the motor loss seen with Parkinson’s disease.

This effect may be due to an effect on the PDE5 enzyme and, more importantly, it may be the result of an effect on the brain.

The researchers also found that sildenafil was associated with an increase in muscle tone. This was not seen with tadalafil.

Tadalafil was also associated with an increase in the level of cGMP. This effect is thought to be caused by the effects of sildenafil on the PDE5 enzyme.

This is the only study to show that sildenafil is associated with an increase in motor function.

The researchers also noted that tadalafil may help people who are already suffering from Parkinson’s disease to return to normalcy. They also noted that, in fact, tadalafil is known to help people who are already using the drug.

If you have any questions about this study, you can contact the National Center for Biotechnology Information (NCBI).

If you would like to submit a request for a copy of the study results, please send your name and email address to the following address: NCBI. NBI. PIT at (1-800-849-2779).

If you would like to see the results of your study, including information about the drugs, send an email to:Research On AgingPIT at (1-800-336-7249).References:
  1. Neuro-Oncology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588147/
  2. Odontoblast-Neuro-Oncology.
  3. Briggs RC.
Research on Aging is a leading publication in thewith peer-reviewed articles in,, and.
  1. https://www.ncbi.nlm.nih.